Technology & Resources
Technical Cores
Translational Technologies and Core Resources Program
Our goal is to provide the highest quality technical services, as well as consultative services, education and mentoring required to best utilize available resources for investigators conducting clinical and translational research.
The Translational Technologies and Core Resources Program is designed to provide "one stop shopping" for clinical and translational researchers looking for services to help them conduct research. In addition to providing research support services, the Program also provides the academic consultation, education, and mentoring necessary to optimally use these resources.
The university currently supports over 60 biomedical cores. Our objective is to guide investigators to the cores that they need to conduct clinical and translational research. The composite list of all current biomedical cores can be found using the M-Cores database.
The direct core resources of this Program consist of the three Michigan Clinical Research Unit (MCRU, formerly General Clinical Research Center (GCRC)) Cores: the Human Applications Laboratory (HAL), Biomedical Imaging Core (BIC), and Sleep Research Laboratory. A brief overview of each is provided below:
Human Application Laboratory (HAL)
Director: Blake Roessler, MD
The HAL provides quality control and quality assurance for current Good Manufacturing Practices and current Good Tissue Practices manufacturing activities needed by MCRU (the former GCRC) approved protocols which involve on-site production of experimental therapeutics.
Educational and training resources for the HAL are provided through the Process Development Core (PDC), a component of the Novel Methodologies Program [link to Novel Methods Program page]. This core provides the technical and regulatory training services necessary to describe, perform, and document the manufacture of an experimental therapeutic under cGLP (Good Laboratory Practice) conditions.
Biomedical Imaging Core (BIC)
Director: Kirk Frey, PhD, MD
The BIC provides imaging resources for pilot data collections and for the production of research radiotracers. It also provides MCRU (former GCRC)-affiliated investigators with:
- access to human resource expertise in the design, execution and interpretation of high-tech imaging studies including, but not limited to, PET and functional MRI (fMRI).
- cutting-edge analytical support of "region of interest" data sets in anatomic brain MRI studies.
Sleep Research Core
Director: Ronald Chervin, MD, MS
The MCRU Sleep Research Core provides essential infrastructure for sleep disorders research conducted by UM investigators with backgrounds in sleep medicine, neurology, pediatrics, psychiatry, psychology, pulmonary medicine, otolaryngology, ophthalmology, and many other fields. Nocturnal polysomnography and daytime Multiple Sleep Latency Tests can be performed for pilot protocols or NIH-supported sleep research projects that have been approved by the MCRU (the former GCRC.) Studies can be performed in the inpatient unit (University Hospital 7A, when open) where two bedrooms and one adjacent control room are equipped for digital polysomnography. Sleep studies can also be performed in the outpatient Michael S. Aldrich Sleep Disorders Laboratory on the 7th floor of the Med Inn Building.
The technical staff of the Sleep Research Core is led by Mark Kingen, RPSGT, and studies are conducted by clinical sleep laboratory staff and the Pediatric Sleep Research Pod. Recordings can include standard polysomnographic recordings of EEG, eye movements, chin EMG, nasal/oral airflow, chest and abdominal excursion, pulse oximetry, snoring, EKG, and leg movements. Time-synched digital video can be included, as can esophageal pressure monitoring, end-tidal CO2 monitoring, and other specialized recording and scoring techniques as required by individual protocols.
For more information about sleep science at the University of Michigan click here.
Requesting Services
Please continue to apply for HAL, BIC and Sleep Lab services using the MCRU (former GCRC) eResearch application: http://www.eresearch.umich.edu/
MICHR services, including Translational Technologies Program, are coordinated through the MICHR Research Development Core.
Phone: 734-998-7474
Email: Um-michr@umich.edu
Contact
Blake J. Roessler, MD
Translational Technologies Program Director
Associate Professor of Internal Medicine
roessler@umich.edu
http://www2.med.umich.edu/departments/internalmedicine/index.cfm...
Kirk Frey, Senior MD, PhD
http://www.umich.edu/~neurosci/faculty/kfrey.htm
Research Professor, MBNI
Professor, Department of Radiology, Nuclear Medicine
Professor, Department of Neurology Scientist
kfrey@umich.edu
Ronald D. Chervin, MD, MS
Michael S. Aldrich Collegiate Professor of Sleep Medicine, Professor of Neurology, and Director, Sleep Disorders Center
http://www.med.umich.edu/neuro/sleeplab/staff/index.htm
chervin@umich.edu
For more information about the MICHR, please call (734) 998-7474 or email um-michr@umich.edu
